For the Summer Games, athletes representing Guinea Bissau first competed at the Games of the XXVI Olympiad Atlanta 1996, taking part there in the sports of athletics and wrestling. For the Winter Games, no athlete representing Guinea Bissau has taken part in the Games editions held between 1924 and 2022. No athlete representing Guinea Bissau has yet won an Olympic Games medal of any colour.
Guinea-Bissau is making its Winter Games debut at the Milan-Cortina 2026 Games.
